Scientists have now provided evidence that the TNF-receptor associated protein-1 (TRAP-1) is what prevents the death of cancer cells.The study by Leav et al was conducted on prostate cancer, which is the second leading cause of cancer death and also the most common variety of cancer in the US, after lung cancer. The group chose [...]
New research has identified a new molecule that prevents lethal mutations in the process of reproduction of cells. Scientists at the Rockefeller University have identified the molecule SMARCAL1 as part of cells’ damage control response to malfunctioning DNA replication. In a usual cell division process, various molecules have specific parts to play in ensuring that [...]
Researchers have discovered that a protein called SPARC is responsible for causing scarring of fat tissue which could be the key to understanding the link between obesity and type 2 diabetes. Read more about Metabolic Endocrinology Type II Diabetes Therapy Area Drug Pipeline Report
Proteomics can be defined as the qualitative and quantitative comparison of proteomes under different conditions to further unravel biological processes. A new fundamental concept called proteome (protein complement to a genome) has recently emerged that should drastically help phenomics to unravel biochemical and physiological mechanisms of complex multivariate diseases at the functional molecular level. A [...]
Bioinformatics is the application of information technology to manage biological information. Computers are used to gather, store, analyze and integrate biological and genetic information, which can then be applied to gene-based drug discovery and development. Bioinformatics is being applied at all stages of the drug discovery chain.
Bioinformatics has played a vital role in the advancement of biomolecular sciences, traditionally focusing upon molecular evolution and structural biology. It has allowed accurate statistical analysis of DNA or amino acid sequences, resulting in effective translation between such sequences, to the benefit of genetics, evolution and biochemistry. Bioinformatics sequence analysis has accelerated genome-sequencing efforts, enabling [...]
Drug development or preclinical development is defined in many pharmaceutical companies as the process of taking a new chemical lead through the stages necessary to allow it to be tested in human clinical trials, although a broader definition would encompass the entire process of drug discovery and clinical testing of novel drug candidates.
Proteomics is essentially protein analysis and, until recently, could be described as a broad classification for a set of technology and bioinformatics platforms aimed at the comprehensive molecular description of the actual protein complement of a given sample. Presently, it is typically associated with systems biology. In this context, powerful new technologies for differential complexity [...]
Biotechnology took a dramatic turn In the 1980’s following the invention of the DNA sequencing approach in 19080 and the discovery of polymerase chain reaction (PCR) in 1983. Biochips emerged as a novel micro technology platform for analysis of bio-molecules. This has culminated in a lively biochip industry with biotechnology company Amersham at the forefront. [...]
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