Milestone payments are becoming an increasingly familiar aspect of many biotech deals, as buyers try to mitigate the risks inherent with big purchases. Take Celgene’s $2.9 billion buyout of Abraxis; the biotech giant set aside $650 million in milestone payments if Abraxis’ key drug Abraxane hit certain goals. “These structures are a great way for [...]
Oncologics, lipid regulators, respiratory agents, antidiabetics and anti-ulcerants are the five largest drug classes by sales. But annual sales are only half the story. Which drug classes are booming, and which have plateaued–or even dropped? IMS Health has released top-line industry data revealing the 15 largest drug classes, and we’ve crunched the numbers to take a closer [...]
Chang Lu and his chemical engineering research group at Virginia Tech have discovered how to “greatly enhance” the delivery of DNA payloads into cells. The description of their work will be featured on the cover of Lab on a Chip, the premier journal for researchers in microfluidics. Lu’s ultimate goal is to apply this technique [...]
For someone with a severe, incurable lung disorder such as cystic fibrosis or chronic obstructive pulmonary disease, a lung transplant may be the only chance for survival. Unfortunately, it’s often not a very good chance. Matching donor lungs are rare, and many would-be recipients die waiting for the transplants that could save their lives.
Building on research work undertaken in Germany, City of Hope investigators near LA have used modified stem cells loaded with gene sequences to fight off HIV. And the scientists in the study say that the work points to a possible cure for the dread virus, which has killed millions of people around the world.
A federal judge struck down patents on two genes linked to breast and ovarian cancer. The decision, if upheld, could throw into doubt the patents covering thousands of human genes and reshape the law of intellectual property. United States District Court Judge Robert W. Sweet issued the 152-page decision, which invalidated seven patents related to [...]
Scorpion venom is notoriously poisonous — but it might be used as an alternative to dangerous and addictive painkillers like morphine, a Tel Aviv University researcher claims. Prof. Michael Gurevitz of Tel Aviv University’s Department of Plant Sciences is investigating new ways for developing a novel painkiller based on natural compounds found in the [...]
Regulatory proteins common to all eukaryotic cells can have additional, unique functions in embryonic stem (ES) cells, according to a study in the Journal of Cell Biology. If cancer progenitor cells — which function similarly to stem cells — are shown to rely on these regulatory proteins in the same way, it may be possible [...]
Scientists in Massachusetts are reporting new evidence that certain high blood pressure drugs may be useful in preventing and treating diabetic retinopathy, the leading cause of vision loss in people with diabetes. The study, the largest to date on proteins in the retina, could lead to new ways to prevent or treat the sight-threatening disease, [...]
Researchers at Boston University have uncovered a DNA sequencing method that requires less DNA than gold standard methods. In general, this makes genome sequencing more reliable. It also decreases cost and the amount of time required to achieve DNA amplification.
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