The molecular machinery that switches on a gene known to cause breast cancer to spread and invade other organs has been identified by an international team led by scientists at The University of Texas M. D. Anderson Cancer Center. The paper was published in Nature Cell Biology’s advanced online publication.
By blocking the cellular signaling activity of a protein, a team of neuroscientists at Cold Spring Harbor Laboratory (CSHL) has prevented memory loss in fruit flies caused by brain plaques similar to those thought to cause Alzheimer’s disease in humans. The study also resolves a long-standing controversy about the role of this protein, PI3 kinase, [...]
Scientists have now provided evidence that the TNF-receptor associated protein-1 (TRAP-1) is what prevents the death of cancer cells.The study by Leav et al was conducted on prostate cancer, which is the second leading cause of cancer death and also the most common variety of cancer in the US, after lung cancer. The group chose [...]
Researchers have discovered that a protein called SPARC is responsible for causing scarring of fat tissue which could be the key to understanding the link between obesity and type 2 diabetes. Read more about Metabolic Endocrinology Type II Diabetes Therapy Area Drug Pipeline Report
Accessory signaling molecules modulate cell-cell interaction by transmission of activation signals and by stimulation of the release of cytokines and chemokines. By these effects, accessory signaling molecules may induce or propagate an inflammatory response. Read more about Transforming Drug Discovery through Genomics and Proteomics
Inflammation is a manifestation of the body’s response to tissue damage and infection. The discovery of the detailed processes of inflammation has revealed a close relationship between inflammation and the immune response. In some diseases, however, the body’s defense system (immune system) triggers an inflammatory response when there are no foreign substances to fight off. [...]
CRP, as C-Reactive Protein is known, is an accessory signaling molecule. CRP modulates cell-cell interaction by transmission of activation signals and by stimulation of the release of cytokines and chemokines. By these effects, accessory signaling molecules may induce or propagate an inflammation. CRP plays a role in inflammation caused by conditions such as nephritis.
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