Milestone payments are becoming an increasingly familiar aspect of many biotech deals, as buyers try to mitigate the risks inherent with big purchases. Take Celgene’s $2.9 billion buyout of Abraxis; the biotech giant set aside $650 million in milestone payments if Abraxis’ key drug Abraxane hit certain goals. “These structures are a great way for [...]
Oncologics, lipid regulators, respiratory agents, antidiabetics and anti-ulcerants are the five largest drug classes by sales. But annual sales are only half the story. Which drug classes are booming, and which have plateaued–or even dropped? IMS Health has released top-line industry data revealing the 15 largest drug classes, and we’ve crunched the numbers to take a closer [...]
Eli Lilly (NYSE: LLY) is looking to its pipeline to fill the gaps left by a number of high-profile drugs coming off patent. In October 2011, blockbuster Zyprexa will fall to generic competition; additionally, about three-quarters of Lilly’s current revenue comes from eight drugs that will lose patent protection between now and 2017. ”We have the challenge [...]
For someone with a severe, incurable lung disorder such as cystic fibrosis or chronic obstructive pulmonary disease, a lung transplant may be the only chance for survival. Unfortunately, it’s often not a very good chance. Matching donor lungs are rare, and many would-be recipients die waiting for the transplants that could save their lives.
Lithium is the most effective treatment for bipolar disorder. However, its use is limited because of neurological side effects and a risk for overdose-induced toxicity. Many of the beneficial effects of lithium are mediated by its inhibition of GSK-3 proteins, but whether this is the mechanism underlying its negative effects has not been determined. However, [...]
Sex “addiction” is a concept that has had particularly high visibility recently with the publicity associated with Tiger Woods. Persons with addictive or compulsive disorders frequently display an inability to inhibit behaviors once they become maladaptive, despite adverse consequences of their behavior. The medial prefrontal cortex (mPFC) is a brain region involved in decision-making and [...]
The molecular machinery that switches on a gene known to cause breast cancer to spread and invade other organs has been identified by an international team led by scientists at The University of Texas M. D. Anderson Cancer Center. The paper was published in Nature Cell Biology’s advanced online publication.
By blocking the cellular signaling activity of a protein, a team of neuroscientists at Cold Spring Harbor Laboratory (CSHL) has prevented memory loss in fruit flies caused by brain plaques similar to those thought to cause Alzheimer’s disease in humans. The study also resolves a long-standing controversy about the role of this protein, PI3 kinase, [...]
Scientists have now provided evidence that the TNF-receptor associated protein-1 (TRAP-1) is what prevents the death of cancer cells.The study by Leav et al was conducted on prostate cancer, which is the second leading cause of cancer death and also the most common variety of cancer in the US, after lung cancer. The group chose [...]
Researchers have discovered that a protein called SPARC is responsible for causing scarring of fat tissue which could be the key to understanding the link between obesity and type 2 diabetes. Read more about Metabolic Endocrinology Type II Diabetes Therapy Area Drug Pipeline Report
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