Archive for the 'General News' Category

Milestones Mitigate Risk in Biotech Deals

Milestone payments are becoming an increasingly familiar aspect of many biotech deals, as buyers try to mitigate the risks inherent with big purchases. Take Celgene’s $2.9 billion buyout of Abraxis; the biotech giant set aside $650 million in milestone payments if Abraxis’ key drug Abraxane hit certain goals. “These structures are a great way for buyer and seller to share the risk that’s related to drug development,” says analyst Brett Skolnik. Milestones also encourage buyer and seller to look beyond the merger, making it more likely the deal will be beneficial to both sides in the long term.

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Utah Doctor Sentenced to Three Years for Illegal Online Pharmacy

A Utah doctor is being sent to jail for his connection to an illegal online pharmacy that sold more than eight million weight-loss pills manufactured in Mexico. Dr James A Brinton was sentenced to three years in a federal penitentiary after he pleaded guilty to conspiracy to distribute phentermine and conspiracy to commit international money laundering, according to the Desert News. The doctor was one of 18 people who were charged with crimes in connection to the Lighthouse Meds website.

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Fastest Growing Therapeutic Classes (by Sales)

Oncologics, lipid regulators, respiratory agents, antidiabetics and anti-ulcerants are the five largest drug classes by sales. But annual sales are only half the story. Which drug classes are booming, and which have plateaued–or even dropped? IMS Health has released top-line industry data revealing the 15 largest drug classes, and we’ve crunched the numbers to take a closer look at the average sales growth of the 15 largest therapeutic classes over the last five years.

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Pipeline to Soften Lilly Patent Losses

Eli Lilly (NYSE: LLY) is looking to its pipeline to fill the gaps left by a number of high-profile drugs coming off patent. In October 2011, blockbuster Zyprexa will fall to generic competition; additionally, about three-quarters of Lilly’s current revenue comes from eight drugs that will lose patent protection between now and 2017. ”We have the challenge of replenishing our product portfolio from our pipeline,” says CEO John Lechleiter in a USA Today interview. “Fortunately, we have the most exciting pipeline today in our history.”

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Specially Engineered Immune Cells Ward off AIDS

A group of scientists have demonstrated that specially engineered stem cells could be used to fights off AIDS, successfully testing the approach in mice engineered to develop immune systems similar to humans. The investigators started with the observation that a small group of people who are virtually immune to HIV have disabled CCR5 receptors on their immune cells–a door the virus uses to infect the cells. The scientists engineered stem cells with the ‘door’ essentially locked, then inserted them into the mice, where they developed into immune cells that were able to guard the mice against HIV.

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Nigeria Takes on Fake Drugs with New Technology

Nigeria is fast-tracking mobile authentication services in its fight against drug counterfeiters. Manufacturers will bear the brunt of the cost, at least initially. The costal country of 150 million is at the forefront of African anti-counterfeiting efforts, thanks largely to a rampant supply of malaria drug fakes. In mid-May, the nonprofit Pedigree Network and computer giant HP launched an authentication trial in Nigeria and Ghana; Nigeria is also conducting tests with Merck using technology from Sproxil.

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Top 10 Pharma CEO Salaries of 2009

Welcome to the annual look at the biggest CEO paychecks in the pharma industry. The major trend in 2009 was the mega-merger, which helped propel former Schering-Plough CEO Fred Hassan to the top of this year’s list. With the help of a $33 million golden handshake, Hassan bypassed perennial top dogs Bill Weldon (Johnson & Johnson) and Miles White (Abbott) as the highest-paid CEO in Pharma.

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Merck KGaA’s Pancreatic Cancer Vaccine Ready for Testing

In the quest for a cancer vaccine, Merck KGaA is again stepping into the ring. Vaximm Holding AG, the company’s joint venture with a Switzerland’s BB Biotech Ventures III, will start testing a therapeutic cancer vaccine in patients next year. The vaccine, VXM01, harnesses the body’s immune system to fight cancer by using T-cells to close off the tumor’s blood supply. Roche’s Avastin also focuses on the tumor’s blood supply, but it focuses on eliminating a protein that creates the blood vessels to the tumor.

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Roche Cedes Power, Jobs to Genentech

Worrywarts who thought Roche would corporatize and homogenize Genentech can rest easy. Roche is veering toward Genentech, rather than the other way around, Bloomberg reports. Even though Roche was the one that bought out Genentech in last year’s $46.8 billion deal, the Swiss drugmaker has named Genentech scientists to key jobs–Hal Barron as head of global development, Ian Clark as chief of Roche’s North American commercial operations, Pat Yang as global manufacturing chief. Genentech veterans have also taken hold farther down the food chain, running marketing teams and commercial-management roles.

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Only the Biggest Developers can play the Biosimilar Game

Over the next five years, the market for biosimilars will swell to $10 billion, but only a handful of players with deep pockets and world-class R&D facilities will be able to play. And that means that most small- and medium-size drug developers will never have a chance of leaping into the new market for follow-on biologics.

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