Archive for the 'Central Nervous System' Category
December 29th, 2010 by admin
A new study is unraveling the earliest events associated with neurodegenerative diseases characterized by abnormal accumulation of tau protein. The research reveals how tau disrupts neuronal communication at synapses and may help to guide development of therapeutic strategies that precede irreversible neuronal degeneration.
Continue reading ‘Alzheimer’s: Tau Disrupts Neural Communication Prior to Neurodegeneration’
August 27th, 2010 by admin
Drug counterfeiting has become a $200-billion business annually, according to the World Customs Organization. By some calculations, the counterfeiting trade has become more lucrative than the narcotics business. It’s a global problem. The World Health Organization estimates that counterfeit drugs make up ten percent of the drug market worldwide. And experts say that solving it–or at least stemming the tide–requires the participation of both government and industry.
Continue reading ‘Drug Counterfeiting – a $200 Billion Business’
July 27th, 2010 by admin
Oncologics, lipid regulators, respiratory agents, antidiabetics and anti-ulcerants are the five largest drug classes by sales. But annual sales are only half the story. Which drug classes are booming, and which have plateaued–or even dropped? IMS Health has released top-line industry data revealing the 15 largest drug classes, and we’ve crunched the numbers to take a closer look at the average sales growth of the 15 largest therapeutic classes over the last five years.
Continue reading ‘Fastest Growing Therapeutic Classes (by Sales)’
July 26th, 2010 by admin
Eli Lilly (NYSE: LLY) is looking to its pipeline to fill the gaps left by a number of high-profile drugs coming off patent. In October 2011, blockbuster Zyprexa will fall to generic competition; additionally, about three-quarters of Lilly’s current revenue comes from eight drugs that will lose patent protection between now and 2017. ”We have the challenge of replenishing our product portfolio from our pipeline,” says CEO John Lechleiter in a USA Today interview. “Fortunately, we have the most exciting pipeline today in our history.”
Continue reading ‘Pipeline to Soften Lilly Patent Losses’
June 25th, 2010 by admin
Lithium is the most effective treatment for bipolar disorder. However, its use is limited because of neurological side effects and a risk for overdose-induced toxicity. Many of the beneficial effects of lithium are mediated by its inhibition of GSK-3 proteins, but whether this is the mechanism underlying its negative effects has not been determined. However, Raquel Gómez-Sintes and José Lucas, at CSIC/UAM, Spain, have now delineated a molecular pathway by which chronic administration of therapeutic doses of lithium has negative effects in mice.
Continue reading ‘Reducing the Toxicity of Lithium’
May 19th, 2010 by admin
After birth the brain loses many nerve cells and this continues throughout life — most neurons are formed before birth, after which many excess neurons degenerate. However, there are some cells that are still capable of division in old age — in the brains of mice, at least. According to scientists from the Max Planck Institute of Immunobiology in Freiburg, different types of neuronal stem cells exist that can create new neurons. While they divide continuously and create new neurons in young animals, a large proportion of the cells in older animals persist in a state of dormancy. However, the production of new cells can be reactivated, for example, through physical activity or epileptic seizures. What happens in mice could also be applicable to humans as neurons that are capable of dividing also occur in the human brain into adulthood.
Continue reading ‘New Nerve Stem Cells — Even in Old Age’
February 11th, 2010 by admin
Researchers know relatively little about medulloblastomas or why some cases respond better to treatments than others. Now, a new study conducted at Queen Mary, University of London has shown how the most common type of children’s brain cancer can develop from stem cells.
Continue reading ‘Relation between Children’s Brain Cancer and Stem Cells’
October 20th, 2009 by admin
We have all experienced intense pain that only lasts for a moment at least once in our lives. But questions arise as to how such severe pain is able to disappear just as fast as it came. We also wonder why it is that other types of equally intense pain experienced do not vanish as quickly but instead remain to become chronic and tormenting to the sufferers. Read more about Bioinformatics Market Potential
Continue reading ‘Pain Is Spread and Prolonged by Active Marijuana Ingredients’
May 6th, 2009 by admin
The pharmaceutical industry comprises establishments primarily engaged in manufacturing drugs, medicines and related products for human or animal use. Establishments in this industry may undertake one or more of several processes, including basic processes, such as chemical synthesis; fermentation; distillation and solvent extraction; grading, grinding and milling; and packaging in forms suitable for internal and external use, such as tablets, vials, ampoules and ointments.
Continue reading ‘Rise of the Indian Pharmaceutical Industry’
